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Retrovirus-mediated gene transfer of MLL-ELL transforms …
The MLL-ELL fusion gene results from the translocation t(11;19)(q23;p13.1) that is associated with de novo and therapy-related acute myeloid leukemia. To study its transforming properties, we retrovirally transduced primary murine hematopoietic progenitors and assessed their growth properties both in vitro and in vivo.MLL-ELL increased the …
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The MLL recombinome of acute leukemias in 2017
Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia ...
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High Expression of BCL11A Predicts Poor Prognosis for Childhood MLL …
Three of these genes, BCL11A, GLT8D1 and NCBP2, were shown to be increased in MLL -r ALL patient bone marrows compared to the non- MLL -r ALL patient. Finally, Kaplan-Meier analysis indicated that childhood ALL patients with high BCL11A expression had significantly poor overall survival. Conclusion: These findings suggest …
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MLL2, not MLL1, Plays a Major Role in Sustaining MLL-rearranged Acute
Impact of MLL1 loss on MLL-FP-initiated AML. To determine the requirement for MLL1 in ongoing leukemia, we established MLL-FP-transformed cells in which the Kmt2a gene (referred to as Mll1) could be deleted upon induction of Cre∷ER T2 (Cre +) using 4-hydroxytamoxifen (4-OHT) or tamoxifen (TAM) (Figure 1A).Two critical controls were …
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RNA binding proteins in MLL-rearranged leukemia
Mixed-lineage leukemia 1 (MLL/KMT2A) MLL/KMT2A is the human homolog of the Drosophila melanogaster trithorax protein, which is known to regulate embryogenesis and homeotic gene expression ().Several groups have shown that homozygous deletion of Mll in mice is embryonic lethal while heterozygous Mll mice display abnormal body …
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For instance, GGX_F1_AB is a FORM 1 instruction that only uses operands A and B, and GGX_F1_NARG is a FORM 1 instruction that uses no operands. Classifying instructions using these values will simplify disassembly. The print_insn_ggx() function now includes support for disassembling generic GGX_F1_NARG instructions (of which "bad" is now a …
Frontiers | Rewiring the Epigenetic Networks in MLL …
Leukemias driven by chromosomal translocation of the mixed-lineage leukemia gene (MLL or KMT2A) are highly prevalent in pediatric oncology. The poor survival rate and lack of an effective targeted therapy for patients with MLL-rearranged (MLL-r) leukemias emphasize an urgent need for improved knowledge and novel therapeutic …
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Trying the Food Delivery App Cari – 2:48AM
Last week Cari, the new food delivery app soft launched in Kuwait. It was more of a beta launch than a soft launch since the app was constantly crashing at first, there were barely any restaurants and there was no sign of one of their most aggressive features which was 30 minutes delivery. Since then there have been at least two software ...
GGX Shading Model For Metallic Reflections
The sphere has a Vray Material set to the Ward shader, the previous best shader for metallic highlights. The shader also has a glossiness below 1 to make it a little rough (ie, the reflection blurry) Ward, 0.96 Glossiness. Now lets change the shader to GGX. GGX, 0.96 Glossiness, Tail 2.0. Now notice that it looks really different.
Glossy BSDF — Blender Manual
Sharp: Results in perfectly sharp reflections like a mirror. The Roughness value is not used. GGX: GGX microfacet distribution. Multiple-scattering GGX: Cycles Only Takes multiple bounce (scattering) events between microfacets into account. This gives a more energy conserving results, which would otherwise be visible as excessive darkening.
GGX BRDF Shader Model
VRED now uses a GGX BRDF model for all materials. This is THE standard for many render engines, as it improves light reflections for rough surfaces, making them look more realistic, by using GGX as this new default BRDF behavior. It allows high fidelity simulation of material reflection at both peek and shallow viewing angles, resulting in a subtle softer …